For a 100% permanent resolution, the community has developed a fantastic modding tool that fixes the core code of the game, making manual tweaks unnecessary.
Windows Security blocks the game from creating save files in the Documents folder. prototype 2 failed to save data fix exclusive
If your Windows user profile folder contains special characters (e.g., symbols, accents), the game cannot find the save path. For a 100% permanent resolution, the community has
If is turned on, click Allow an app through Controlled folder access . For a 100% permanent resolution