Never run activator tools, keygens, or "patches" downloaded from unknown sources. The cost of recovering from ransomware or identity theft far exceeds the price of a legitimate software license.
Developers track leaked serial numbers and block them in subsequent database updates.
If portability is your primary goal, you can make many legitimate, installed programs portable using . These are tools designed to repackage standard Windows applications so they can run from a USB drive. However, you still need a legal license for the original software.