To prevent the file from being deleted again, you must tell your antivirus to ignore the game folder. Windows Security Exclusions (under Virus & threat protection settings). Add an exclusion and pick the folder where your Hitman: Absolution portable files are located. Manual Download (Alternative)

Please attempt the following fixes in order.

If you're using a portable version of the game, ensure it's a trusted source and consider the following:

Portable games sometimes fail because the host system lacks required runtime libraries. Ensure you have updated.