The problem arises because Uncharted 4: Legacy of Thieves Collection on PC was compiled to rely heavily on AVX2 instructions. Unlike some other games that include "fallback" code for older processors, Uncharted 4 attempts to execute these instructions immediately upon startup. If your CPU was released before 2013 (specifically Intel 4th Gen Haswell or older), your hardware cannot understand these instructions, leading to an instant crash.
from the v1 and v2 eras (e.g., E5-2670)
: These fallback executables use standard instruction sets or original AVX paths to perform the floating-point computations that were previously locked to AVX2. Preserved High-End Performance uncharted 4 avx2 fix